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From203US$ /night
Check-in
12Jan2026Select date
Check-out
13Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
-
Steps from Mayo Clinic
Great
8.9
9.3
/10
4.6
4.5
/5

The 3-star Residence Inn By Marriott Jacksonville-Mayo Clinic Area is situated in a business area of Jacksonville, 10 minutes by car from the Mind Bender Escape Rooms and 4.2 km from the Paws Park. Boasting an outdoor swimming pool and a fitness studio, the hotel offers access to the raised trails "Castaway Island Preserve", which is 4 km away.

Location

This Jacksonville hotel lies in the Southpoint-Butler Blvd district, 50 minutes by car from Union train station.

For those travelling from afar, Jacksonville International airport is 40 minutes' drive away.

Rooms

The Residence Jacksonville offers 181 rooms, some of them feature free wireless internet and a television with satellite channels, as well as comforts such as blackout drapes and an ironing board. They are also complete with a fridge, a stove top, and a dishwasher. Providing a roll-in shower and a separate toilet, some bathrooms come with a hair dryer and bath sheets.

Eat & Drink

Guests are welcome to the poolside bar to relax with a drink.

Leisure & Business

The Residence includes a sundeck, a shared lounge, and barbecue grills on site. Guests are welcome to take part in bicycle usage. Those on a business trip will benefit from a xerox and complimentary wireless internet access provided on site.

“This hotel stands out as a thoughtfully designed property near the Mayo Clinic. I'm impressed by the spacious suites equipped with full kitchens, a crucial amenity for extended stays and the pet-friendly atmosphere, complete with dedicated areas for furry companions is a real advantage. I particularly appreciate the commitment to guest comfort, extending to details like a lounge designed for relaxation.”
Hotel logo
James DavidEditor-in-Chief at Dogfriendly-hotels
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Select your room type

The hotel provides many room choices—family rooms, doubles, and pet-friendly suites—with breakfast, free cancellation, and special offers
One-Bedroom Queen Suite Hearing Accessible
2 persons
52 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
King Studio Suite Sofa Bed Adapted Tub Mobility Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
Queen Corner Suite
2 persons
60 m² 
1 King-size bed and 1 Sofa bed
Shower
Coffee machine
King Studio Suite Sofa Bed Hearing Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
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Rates & availability calendar

See current prices and availability for your chosen dates!

Facilities

Hotels feature amenities designed to keep both you and your pet comfortable

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Lift
  • Fireplace
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Golf course

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Free shuttle service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Grocery shopping service
  • Shops/Commercial services

Dining

  • Bar/ Lounge area
  • Picnic area/ Tables

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet
  • Board games

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Heated swimming pool
  • Outdoor swimming pool
  • Sun loungers
  • BBQ facilities
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Dining table

Bathroom

  • Free toiletries
  • Sink

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Hotel location

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Map view
4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Nearby
Hospital
Mayo Clinic Jacksonville
1.0 km
Restaurants
Bundy Cafe & Atrium
910 m
4500 San Pablo Rd S Mayo Clinic
Explore Jacksonville
Explore Jacksonville
Top Attractions
Activities
Dining
Entertainment
Mayo Clinic Jacksonville
Mayo Clinic Jacksonville
12 minutes' walk
Renowned medical institution offering exceptional services and innovations in healthcare.
Harbor City Municipal Golf Course
Harbor City Municipal Golf Course
5 minutes' drive
A scenic 18-hole course featuring well-maintained greens, perfect for golfers of all skill levels.
Windsor Parke Golf Club
10 minutes' drive
Challenging 18-hole course set amidst natural landscapes, great for both relaxation and competition.
Adventure Landing Jacksonville Beach
Adventure Landing Jacksonville Beach
10 minutes' drive
Thrilling amusement park featuring water slides, mini-golf, and go-karts, ideal for families and thrill-seekers.
Castaway Island Preserve
Castaway Island Preserve
8 minutes' drive
A serene nature preserve with walking trails perfect for relaxation and enjoying the local flora and fauna.
Bundy Cafe & Atrium
Bundy Cafe & Atrium
10 minutes' walk
Cozy cafe known for hearty breakfasts and fresh coffee. Offers vegetarian options and a friendly atmosphere.
Ocean 60
10 minutes' drive
Upscale seafood restaurant featuring creative dishes and waterfront views. Reservations recommended on weekends.
Regal Beach Boulevard 18
Regal Beach Boulevard 18
10 minutes' drive
A modern cinema offering the latest movies in comfortable settings, also hosts special screenings and events.
Mind Bender Escape Rooms
Mind Bender Escape Rooms
10 minutes' drive
Interactive escape rooms designed for group fun, great for families and friends looking for unique challenges.
Local transport and travel tips
City Centre
Jacksonville35 min  ·  22.7 km
Airports
Jacksonville International Airport (JAX)67 min  ·  44.6 km
St. Augustine, FL (UST)71 min  ·  47.0 km
Train
Jacksonville Electric Authority Southside Generating Station Wharf30 min  ·  19.8 km
Union Station36 min  ·  24.0 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
Public parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Pets
Pets are allowed on request.
Number of floors:
7
Number of rooms:
181
Former name
residence inn by marriott jacksonville - mayo clinic area
FAQs
About Residence Inn By Marriott Jacksonville-Mayo Clinic Area
What is the check-in and check-out policy at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Check-in is from 16:00 and check-out is by 11:00.
How far is Residence Inn By Marriott Jacksonville-Mayo Clinic Area from Jacksonville International Airport?
The hotel is located 43 km from Jacksonville International Airport.
What are the available room amenities at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Rooms feature air conditioning, a flat-screen TV with satellite channels, a kitchen with cooking facilities, and a private bathroom with complimentary toiletries.
What dining options are available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel provides complimentary buffet breakfast and features an on-site bar with food service offering healthy options.
Is parking available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Public parking is available on-site free of charge, and no reservation is needed.
What recreational facilities can guests enjoy at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel includes an outdoor swimming pool and a fitness centre.
What business facilities does Residence Inn By Marriott Jacksonville-Mayo Clinic Area offer?
The hotel offers a 24-hour business center and meeting spaces available for business needs.
Which popular attractions are near Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Nearby attractions include Mayo Clinic Florida (2 minutes by car) and St Johns Town Center (9 minutes drive).
What kind of breakfast does Residence Inn By Marriott Jacksonville-Mayo Clinic Area serve?
Guests can enjoy a complimentary buffet or American breakfast.
What languages are spoken by the staff at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The staff speaks English and Spanish.
Is a shuttle service available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
A complimentary hourly shuttle is available from 7 am to 5 pm to medical facilities and local attractions.

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